Article

OBJECTIVE: To investigate the effect of dual-mode noninvasive brain stimulation
(NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS)
over the primary motor cortex of the lower leg and anodal transcranial direct
current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared
with rTMS alone in patients with Parkinson disease (PD) with freezing of gait
(FOG). DESIGN: Randomized, double-blind, controlled study. SETTING: Outpatient
rehabilitation clinics. PARTICIPANTS: Patients diagnosed as having PD with FOG
(N=32). INTERVENTIONS: Patients in the dual-mode group underwent 5 consecutive
daily sessions of dual-mode NIBS with high-frequency rTMS and tDCS
simultaneously, whereas patients in the rTMS group underwent high-frequency rTMS
and sham tDCS. MAIN OUTCOME MEASURES: Assessments of FOG and motor, ambulatory,
and cognitive function were performed 3 times: at baseline before NIBS,
immediately after NIBS, and 1 week after cessation of NIBS. RESULTS: Serious
adverse effects were not observed in either group. Significant changes over time
were observed in FOG, motor function, and ambulatory function in each group;
however, there was no significant difference between the 2 groups. Executive
function showed significant improvement after NIBS only in the dual-mode group.
CONCLUSIONS: These results suggest the potential for dual-mode NIBS to modulate 2
different cortices simultaneously. Dual-mode NIBS might be considered a novel
therapeutic approach for patients with PD.
CI - Copyright (c) 2017 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS