- CConnexion
RééDOC
75 Boulevard Lobau 54042 NANCY cedex Christelle Grandidier Documentaliste 03 83 52 67 64 0
|
Alendronate in the treatment of low bone mass in steroid-treated boys with Duchenne's muscular dystrophy
HAWKER GA; RIDOUT R; HARRIS VA
ARCH PHYS MED REHABIL , 2005, vol. 86, n° 2, p. 284-288 Doc n°: 118141 Localisation : Documentation IRR Descripteurs : AB311 - MYOPATHIE DE DUCHENNE DE BOULOGNE, DA6 - TRAITEMENTS - APPAREIL LOCOMOTEUR
Article consultable sur : http://www.archives-pmr.org
Objective: To examine alendronate's side-effect profile and effect on bone mineral density (BMD) in deflazacort-treated boys with Duchenne's muscular dystrophy (DMD) and low BMD. Design: Before-after trial. Setting: Neuromuscular clinic at a children's hospital in Canada between 1999 and 2000. Participants: All consenting boys with DMD who had z scores less than -1.00 (spine and/or total body) and in whom BMD testing was feasible. Intervention: Boys received .08 mg(.)kg(-1.)d(-1) of alendronate orally, with 750mg of daily calcium and 1000IU of vitamin D. BMD, height, weight, physical activity, Tanner stage, and adverse effects were followed for 2 years. Main Outcome Measures: BMD z scores at the lumbar spine (L1-4) and total body. Results: Of the 42 eligible boys assessed, 23 had low BMD; for 16 of the 23, future BMD testing was feasible. Mean age was 10.8 years (range, 6.9-15.6y). Mean baseline z scores at the total body and spine were -0.80 and -1.94, respectively. At 2 years, mean z scores were unchanged. Furthermore, alendronate response varied by baseline age. In multivariable analysis, improvement in total body and spine z scores was associated with younger age at baseline (P=.01 for both). Conclusions: In deflazacort-treated boys, alendronate had a positive effect on BMD z scores; the effect was greatest when given early in the course of disease. Langue : ANGLAIS |
0
|