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Fibromyalgia : The nerve of that disease
LEVINE JD; REICHLING DB
J RHEUMATOL , 2005, vol. 32, n° SUPPL. 75, p. 29-37 Doc n°: 121723 Localisation : Bibliothèque Universitaire de Médecine de Nancy Descripteurs : DA52 - MALADIES RHUMATISMALES Fibromyalgia syndrome (FM) is a common, often debilitating and intractable, chronic, generalized pain condition. The development of effective therapies to treat FM has been hindered by a lack of understanding of fundamental mechanisms in the etiology of FM. In view of prominent characteristics that FM shares with other generalized pain conditions, we suggest that a key mechanism in such disorders may be that of altered activity in the subdiaphragmatic vagus nerve. Specifically, we propose that activity in vagal afferents, arising from the gastrointestinal tract, and sympathoadrenal function mediate a contribution of stress to FM and its strong association with irritable bowel syndrome. Langue : ANGLAIS |
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