Article

OBJECTIVE: To determine whether physical activity may affect cognitive
performance in patients with Parkinson's disease by measuring reaction times in
patients participating in the Berlin BIG study. DESIGN: Randomized controlled
trial, rater-blinded. SETTING: Ambulatory care. PARTICIPANTS: Patients with mild
to moderate Parkinson's disease (N=60) were randomly allocated to 3 treatment
arms. Outcome was measured at the termination of training and at follow-up 16
weeks after baseline in 58 patients (completers). INTERVENTIONS: Patients
received 16 hours of individual Lee Silverman Voice Treatment-BIG training (BIG;
duration of treatment, 4wk), 16 hours of group training with Nordic Walking
(WALK; duration of treatment, 8wk), or nonsupervised domestic exercise (HOME;
duration of instruction, 1hr). MAIN OUTCOME MEASURES: Cued reaction time (cRT)
and noncued reaction time (nRT). RESULTS: Differences between treatment groups in
improvement in reaction times from baseline to intermediate and baseline to
follow-up assessments were observed for cRT but not for nRT. Pairwise t test
comparisons revealed differences in change in cRT at both measurements between
BIG and HOME groups (intermediate: -52ms; 95% confidence interval [CI], -84/-20;
P=.002; follow-up: 55ms; CI, -105/-6; P=.030) and between WALK and HOME groups
(intermediate: -61ms; CI, -120/-2; P=.042; follow-up: -78ms; CI, -136/-20;
P=.010). There was no difference between BIG and WALK groups (intermediate: 9ms;
CI, -49/67; P=.742; follow-up: 23ms; CI, -27/72; P=.361). CONCLUSION: Supervised
physical exercise with Lee Silverman Voice Treatment-BIG or Nordic Walking is
associated with improvement in cognitive aspects of movement preparation.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS