Article

This investigation explored how aerobic interval training influences
central or peripheral hemodynamic response(s) to exercise in patients with heart
failure (HF) with preserved ejection fraction (HFpEF) or those with HF with
reduced ejection fraction (HFrEF). DESIGN: One hundred twenty HF patients were
divided into four groups: HFpEF and HFrEF with aerobic interval training (3-min
intervals at 40% and 80% VO2peak for 30 mins/day, 3 days/wk for 12 wks) and
general health care groups. Exercise hemodynamics in the heart, frontal cerebral
lobe, and vastus lateralis muscle, and oxygenation in the frontal cerebral lobe
and vastus lateralis muscle were measured before and after the intervention.
RESULTS: Aerobic interval training significantly (1) improved pumping function
with enhanced peak cardiac power index in the HFrEF group and improved diastolic
function with reduction of the E/E' ratio in the HFpEF group, (2) increased blood
distribution to the frontal cerebral lobe/vastus lateralis muscle and O2
extraction by vastus lateralis muscle during exercise in the HFpEF group compared
with the HFrEF group, (3) heightened VO2peak in both HFpEF and HFrEF groups and
lowered the VE/VCO2 slope in the HFpEF group, and (4) increased the Short Form-36
physical/mental component scores and decreased the Minnesota Living with Heart
Failure questionnaire score in both HFpEF and HFrEF groups. CONCLUSIONS: Aerobic
interval training effectively enhances cardiac hemodynamic response to exercise
in HFrEF patients while increasing the delivery/use of O2 to exercising skeletal
muscles and frontal cerebral lobe tissues in HFpEF patients, thereby improving
global/disease-specific quality-of-life measures in these HF patients.

Langue : ANGLAIS