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Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone
TEO JCM; SIHOE KM; KEH JEL; TEOH SH
CLIN BIOMECH , 2006, vol. 21, n° 3, p. 235-244 Doc n°: 123885 Localisation : Documentation IRR Descripteurs : DA6 - TRAITEMENTS - APPAREIL LOCOMOTEUR In vivo assessment of bone density is insufficient for the evaluation of osteoporosis in patients. A more complete diagnostic tool for the determination of bone quality is needed. Micro-computed tomography imaging allows a non-destructive method for evaluating cancellous bone micro-architecture. However, lengthened exposure to ionizing radiation prevents patients to be imaged by such a system. The aim for this study was to elucidate the relationships between image intensity (of Hounsfield units), cancellous bone micro-architecture and mechanical properties. Methods. Using pig vertebral cancellous bone, the bone specimens were imaged using clinical and micro-computed tomography scanners and subsequently subjected to uniaxial compression testing. Results. Results indicate that micro-architecture can be predicted using clinical image intensity. Micro-architectural parameters relevant to osteoporosis study, such as percent bone volume, trabecular bone pattern factor, structure model index, trabecular thickness and trabecular separation have shown significant correlation with R-2 values of 0.83, 0.80, 0.70, 0.72, and 0.54, respectively, when correlated to Hounsfield units. In addition, the correlation of mechanical properties Langue : ANGLAIS |
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