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Congenital cytomegalovirus is associated with severe forms of cerebral palsy and female sex in a retrospective population-based study

SMITHERS SHEEDY H; RAYNES GREENOW C; BADAWI N; MCINTYRE S; JONES C
DEV MED CHILD NEUROL , 2014, vol. 56, n° 9, p. 846-852
Doc n°: 170267
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1111/dmcn.12467
Descripteurs : AJ23 - PARALYSIE CEREBRALE

Congenital cytomegalovirus (cCMV) infection can result in poor outcomes
including cerebral palsy (CP). The aim of this study was to describe the
incidence and comorbidities of CP reported to the Australian Cerebral Palsy
Register (ACPR) as attributed to cCMV infection.
METHOD: This was a retrospective
population-based study. Cases were drawn from Australian state CP registers with
population level ascertainment, 1993 to 2003 (n=2265; 56.4% males, Gross Motor
Function Classification System [GMFCS] ratings available for Victorian cases
only: 70% GMFCS levels I to III and 30% GMFCS levels IV to V). Clinical data were
extracted and cases with cCMV reported as a known cause were compared with cases
where cCMV was not reported. RESULTS: Children with cCMV
(n=34; 12 males, 22
females; mean [SD] gestational age, 36.4 wk [4.4], range 24-41 wk) accounted for
1.5% of CP cases; 2.9 per 100 000 live births, (95% confidence intervals
1.9-3.9). When compared with CP cases where cCMV was not reported,
proportionally, more CP cases with cCMV were born to younger mothers (p<0.001),
were female (64% vs 43%, p=0.014), had spastic quadriplegia (73% vs 21%,
p<0.001), required wheeled mobility i.e. GMFCS IV or V (78% vs 28%,
p<0.001), had
epilepsy (70% vs 30%, p<0.001), deafness (40% vs 2%, p<0.001), functional
blindness (20% vs 5%, p<0.001), and severe communication impairment (71% vs 25%,
p<0.001). INTERPRETATION: cCMV is an important potentially preventable cause of
CP and is associated with severe disability and female sex in cases reported to
the ACPR. Future studies utilising prospective sample collection for cCMV testing
are needed to confirm these findings.
CI - (c) 2014 Mac Keith Press.
- CMV

Langue : ANGLAIS

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