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Cyproheptadine for intrathecal Baclofen withdrawal
MEYTHALER JM; ROPER JF; BRUNNER RC
ARCH PHYS MED REHABIL , 2003, vol. 84, n° 5, p. 638-642 Doc n°: 108806 Localisation : Documentation IRR Descripteurs : AD32 - SPASTICITE
Article consultable sur : http://www.archives-pmr.org
Objective: To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal. Design: Descriptive case series. Setting: University hospital with a comprehensive in- and outpatient rehabilitation center. Participants: Four patients (3 with spinal cord injury, 1 with cerebral palsy) with implanted ITB infusion pumps for treatment of severe spasticity, who had ITB withdrawal syndrome because of interruption of ITB infusion. Interventions: Patients were treated with 4 to 8mg of cyproheptadine by mouth every 6 to 8 hours, 5 to 10mg of diazeparn by mouth every 6 to 12 hours, 10 to 20mg of baclofen by mouth every 6 hours, and ITB boluses in some cases. Main Outcome Measures:' Clinical signs and symptoms of ITB withdrawal of varying severity were assessed by vital signs (temperature, heart rate), physical examination (reflexes, tone, clonus), and patient report of symptoms (itching, nausea, headache, malaise). Results: Langue : ANGLAIS Identifiant basis : 2003226901 |
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