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Validation of US cerebral palsy growth charts using a UK cohort

WRIGHT CM; REYNOLDS L; INGRAM E; COLE TJ; BROOKS J
DEV MED CHILD NEUROL , 2017, vol. 59, n° 9, p. 933-938
Doc n°: 184456
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1111/dmcn.13495
Descripteurs : AJ23 - PARALYSIE CEREBRALE

Growth charts for cerebral palsy (CP) have been constructed using data for
24 920 Californian patients, covering ages 2 to 20 years,
with separate charts
for the five severity levels of the Gross Motor Function Classification System
(GMFCS). Our aim was to test how the data for British children with CP fit these
charts, compared with conventional local charts. METHOD:
US CP growth reference
was reanalysed using the lambda-mu-sigma (LMS) method to allow calculation of
standard deviation z-scores. Growth data for 195 children with CP in Glasgow, UK,
were retrieved and converted to z-scores using the CP reference as well as the
combined World Health Organization and UK 1990 growth reference (UK-WHO).
RESULTS: Compared to the UK-WHO reference, measurements diverged progressively
with increasing severity, with mean height for GMFCS level V being close to the
second UK-WHO centile. Compared with the CP reference, mean height and weight
z-scores were between the 50th and 75th centiles for all severity levels, while
body mass index was just below the 50th centile. INTERPRETATION: British children
with severe CP seem relatively very small when their growth data are plotted on
non-CP charts, but their data for weight and body mass index fit well to US CP
charts and reasonably well for height. The LMS look-up tables will make it possible to calculate z-scores and produce charts in local formats.
CI - (c) 2017 Mac Keith Press.

Langue : ANGLAIS

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