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Secondary degeneration reduced by inosine after spinal cord injury in rats
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LIU F; YOU SW; YAO LP; LIU H; JIAO XY; SHI M; ZHAO QB; JU G
SPINAL CORD , 2006, vol. 44, n° 7, p. 421-426 Doc n°: 126144 Localisation : Centre de Réadaptation de Lay St Christophe , en ligne Descripteurs : AE21 - ORIGINE TRAUMATIQUE Url : http://www.nature.com/sc/archive/index.html Assessment of the potential protective effects of inosine on an animal model of spinal cord injury. OBJECTIVES: Our previous studies have demonstrated that inosine can directly protect neurons in vitro from zinc-induced injury and axotomized retinal ganglion cells of rats in vivo. This investigation was carried out to examine the possible protective effects of inosine on spinal cord secondary degeneration. SETTING: Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China. METHODS: Compressive spinal cord injury (95-g load for 1 min) model was established in rats, and inosine was administrated beginning at different time points (2, 12, or 24 h) after spinal cord injury. RESULTS: Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) technique and hematoxylin and eosin staining, our study demonstrated that administration of inosine as late as 12 h after injury significantly reduced the total volume of spinal cord degenerative areas and the number of apoptotic cells 3 days following the trauma. CONCLUSION: Inosine can significantly reduce the spread of secondary degeneration and the cell death following spinal cord injury in adult rats. These findings may find a clinical application in the treatment of acute spinal cord injury. Langue : ANGLAIS |
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