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Gene therapy of mitochondrial DNA mutations
ZULLO SJ
SEMIN NEUROL , 2001, vol. 21, n° 3, p. 327-335 Doc n°: 102889 Localisation : Documentation IRR Descripteurs : AA - GENERALITES - SYSTEME NEUROMUSCULAIRE Successful treatment of mitochondrial DNA (mtDNA) mutations might be possible by construction of mtDNA-encoded protein genes so that they can be inserted into the nuclear genome and the protein expressed in the mitochondria (allotopic expression). This technique would require individual assembly of all 13 mtDNA-encoded protein genes with an aminoterminal leader peptide that directs the cytoplasmic translated protein to the mitochondrial membrane. Langue : ANGLAIS Tiré à part : OUI Identifiant basis : 2001219357 |
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