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Skeletal muscle disease in alcoholism
HALLER RG; KNOCHEL JP
MED CLIN NORTH AM , 1984, vol. 68, n° 1, p. 91-103 Doc n°: 24764 Localisation : Bibliothèque Universitaire de Médecine de Nancy Descripteurs : AB36 - AUTRES PATHOLOGIES MUSCULAIRES Acute alcoholic myopathy is a syndrome of sudden muscle necrosis which occurs in the setting of binge drinking. The clinical expression of muscle injury ranges from an asymptomatic elevation in serum creatine kinase to fulminant rhabdomyolysis with muscle pain, swelling and myoglobinuria. Clinical and experimental studies suggest that this represents a "toxic" myopathy ; however, the cellular basis of the postulated myotoxic effect of ethanol is unknown. Chronic alcoholic myopathy is a more indolently evolving syndrome of proximal weakness and muscle atrophy which accompanies prolonged alcohol abuse. Type II muscle fiber atrophy, the major histologic feature of this disease, is also common in alcoholics without symptoms of muscle disease and supports the notion of a "subclinical" chronic alcoholic myopathy. Langue : ANGLAIS Identifiant basis : 1985092467 |
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