- CConnexion
![]()
RééDOC
75 Boulevard Lobau 54042 NANCY cedex Christelle Grandidier Documentaliste 03 83 52 67 64 0
|
Prevention of spinal epidural fibrosis by recombinant tissue plasminogen activator in rats
H
KEMALOGLU S; OZKAN U; YILMAZ F
SPINAL CORD , 2003, vol. 41, n° 8, p. 427-431 Doc n°: 110114 Localisation : Centre de Réadaptation de Lay St Christophe , en ligne Descripteurs : AE5 - TUMEUR - MOELLE Url : http://www.nature.com/sc/archive/index.html A randomized-controlled experimental study was conducted to investigate the effectiveness of recombinant tissue plasminogen activator (rt-PA) on postlaminectomy epidural fibrosis in rats. SETTING: Diyarbakir, Turkey. METHODS: In a rat model, allowing objective histopathological quantification, the postoperative epidural scar formation was investigated and the potential of local rt-PA in preventing the production of epidural fibrosis was assessed. Rats were randomly allocated to local rt-PA (12 rats) or control (12 rats). RESULTS: Findings suggest a beneficial effect of rt-PA in decreasing the epidural fibrosis following laminectomy when compared with control groups for all investigated parameters such as intermuscular scar (P=0.04), middle scar (P=0.001), deep scar (P=0.001) and dural adhesion (P=0.01) except new bone formation. The presence of arachnoiditis was less in treatment group (P=0.01). CONCLUSION: In rats, the topical thrombolysis with rt-PA is safe and efficacious in preventing postlaminectomy epidural fibrosis. This Thrombolytic therapy with rt-PA after spine surgery may come to play an important role in the prevention of epidural fibrosis and arachnoiditis. Langue : ANGLAIS Identifiant basis : 2003228215 |
0
|