Article

This study aims to investigate changes that occur during progression
and establishment of physiological and pathological cardiac hypertrophy, by
microarray technology and functional annotations. Myocardial
infarction leading to heart failure was induced in rats, with animals killed 1,
3, 7, 14, 42, and 92 days after coronary artery ligation. A second group was
subjected to daily treadmill exercise and killed 1, 4, 24, and 48 h after a
single exercise bout, or after 28 or 56 days of exercise training. RESULTS:
Physiological hypertrophy was associated with less transcriptional alternation
than pathological hypertrophy, indicating that posttranscriptional and
translational regulation may be more important. The main difference between the
two types of hypertrophy was that myocardial infarction was associated with
downregulation of genes related to fatty acid metabolism, whereas no such change
occurred after exercise training. Thus, fatty acid metabolism may distinguish
adverse maladaptive hypertrophy from beneficial adaptive hypertrophy. CONCLUSION:
This study points to specific genes and gene classes related to biological
processes that may be important in these well-characterized rat models of
physiological and pathological cardiac hypertrophy.

Langue : ANGLAIS

Tiré à part : OUI