Article

OBJECTIVE: To determine the association between thiazide use and lower extremity
fractures in patients who are men with a spinal cord injury (SCI). DESIGN: Cohort
study from fiscal years 2002 to 2007. SETTING: Medical centers. PARTICIPANTS: Men
(N=6969) with an SCI from the Veterans Affairs (VA) Spinal Cord Dysfunction (SCD)
Registry, including 1433 users of thiazides and 5536 nonusers of thiazides.
INTERVENTION: Thiazide use versus nonuse. MAIN OUTCOME MEASURE: Incident lower
extremity fractures. RESULTS: Among the men, 21% in the VA SCD Registry (fiscal
years 2002-2007) included in these analyses used thiazide diuretics. There were
832 incident lower extremity fractures over the time period of this study: 110
fractures (7.7%) in 1433 thiazide users and 722 fractures (13%) in 5536 nonusers
of thiazides. In unadjusted and adjusted models alike, thiazide use was
associated with at least a one-quarter risk reduction in lower extremity fracture
at any given point in time (unadjusted: hazard ratio (HR)=.75; 95% confidence
interval (CI), .59-.94; adjusted: HR=.74; 95% CI, .58-.95). CONCLUSIONS: Thiazide
use is common in men with SCI and is associated with a decreased likelihood for
lower extremity fractures.
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Langue : ANGLAIS