Article

Alzheimer's disease (AD) is a progressive neurodegenerative disorder
with an as yet poorly understood etiology. Both environmental and genetic factors
have been implicated as predisposing factors. The apolipoprotein E (APOE)
varepsilon4 allele is an established genetic susceptibility factor for AD for
several populations including the Tunisian population. Polymorphism rs769446
(-427 T/C) at the promoter region of the APOE gene is postulated to affect the
expression of the gene through differential binding of transcription factors.
This study aims at examining the APOE promoter polymorphism rs769446 for
possible association with AD in a Tunisian population.
METHODS: Using a
case-control study design, a sample of 85 patients and 90 controls were
investigated for association with the rs769446 polymorphism. RESULTS: No evidence
of association was found in this population upon comparison between patients and
healthy controls or upon stratification by APOE varepsilon4. CONCLUSIONS:
Investigations of potential gene-gene and gene-environmental interactions for
this polymorphism need to be further conducted.
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Langue : ANGLAIS