Article

OBJECTIVE: To systematically review evidence of treatments for cognitive
impairments experienced by at least 20% of all women who undergo chemotherapy for
breast cancer. DATA SOURCES: Searches of 5 databases (PubMed, Embase, Cochrane
CENTRAL, PsycINFO, CINAHL), with no date or language restrictions, identified
1701 unique results. Search terms included breast cancer, chemotherapy,
chemobrain, chemofog, and terms on cognition and language deficits. STUDY
SELECTION: Included only peer-reviewed journal articles that described therapies
for cognitive dysfunction in women undergoing (or who had undergone) chemotherapy
for breast cancer and provided objective measurements of cognition or language.
DATA EXTRACTION: Data were extracted according to Cochrane recommendations,
including characteristics of participants, interventions, outcomes, and studies.
Quality assessment of all 12 eligible studies was performed using the
Physiotherapy Evidence Database scale and treatment fidelity criteria. Screening,
data extraction, and quality assessment reliability were performed. DATA SYNTHESIS: Six articles described interventions for cognition that took place
during cancer treatment; 6, afterward. Five interventions were medical (including
a strength-training program), 2 were restorative, and 5 were cognitive. Medicinal
treatments were ineffective; restorative and exercise treatments had mixed
results; cognitive therapy had success in varying cognitive domains. The domains
most tested and most successfully treated were verbal memory, attention, and
processing speed. CONCLUSIONS: Cognitive therapy protocols delivered after
chemotherapy and aimed at improving verbal memory, attention, and processing
speed hold the most promise. Future research is needed to clarify whether
computerized cognitive training can be effective in treating this population, and
to identify objective assessment tools that are sensitive to this disorder.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS