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The effect of total cumulative dose, number of treatment cycles, interval between injections, and length of treatment on the frequency of occurrence of antibodies to botulinum toxin type A in the treatment of muscle spasticity

BAKHEIT AM; LIPTROT A; NEWTON R; PICKETT AM
INT J REHABIL RES , 2012, vol. 35, n° 1, p. 36-39
Doc n°: 157163
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1097/MRR.0b013e32834df64f
Descripteurs : AD32 - SPASTICITE

A large cumulative dose of botulinum toxin type A (BoNT-A), frequent injections,
a short interval between treatment cycles, and a long duration of treatment have
all been suggested, but not confirmed, to be associated with a high incidence of
neutralizing antibodies to the neurotoxin. The aim of this study was to
investigate whether these variables predispose to BoNT-A neutralizing antibody
formation. A mouse protection (neutralization) bioassay was used for the
detection of BoNT-A antibodies in 17 patients who received large doses of BoNT-A,
over at least 10 consecutive treatment cycles or for 5 years or more. BoNT-A
antibodies were not detected in any of the study patients. The study findings did
not confirm an association between the above-mentioned variables and BoNT-A
antibody formation.

Langue : ANGLAIS

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