Article

The aim of this study was to estimate the minimal clinically important
difference (MCID) for 6-min walk distance (6MWD) in patients with fibromyalgia.
DESIGN: Data from a recently completed trial that included 187 patients who
completed the 6-min walk test, Fibromyalgia Impact Questionnaire (FIQ), and
Short-Form 36 (SF36) at 12 and 36 wks were used to examine longitudinal changes
in 6MWD. An anchor-based approach that used linear regression analyses was used
to determine the MCID for 6MWD, using the total FIQ score (FIQ-Total) and
SF36-physical function domain as clinical anchors. RESULTS: The mean (SD) change
in 6MWD from baseline to week 36 was 34.4 (65.2) m (P < 0.001). The anchor-based
MCIDs for the 6MWD were 156 and 167 m for the FIQ and SF36-physical function
domain, respectively. These MCIDs correspond with clinically meaningful
improvements in FIQ (14% reduction) and SF36-physical function domain (10-point
increase). CONCLUSION: The MCID for 6MWD in patients with fibromyalgia was 156 to
167 m. These findings provide the first evidence of the change in 6MWD that is
perceived by patients to be clinically meaningful. Further research using other
MCID calculation methods is needed to refine estimates of the MCID for 6MWD in
patients with fibromyalgia.

Langue : ANGLAIS