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Syndrome de Turcot confirmé par biologie moléculaire
JEANNIN S; LEBRUN C; VAN DEN BOS F; OLSCHWANG S; BOURG V; FRENAY M
REV NEUROL (Paris) , 2006, vol. 162, n° 6-7, p. 741-746 Doc n°: 126081 Localisation : Documentation IRR Descripteurs : AD12 - PATHOLOGIQUE - ETUDES GENERALES - SEMIOLOGIE ET SYNDROMES CENTRAUX Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and a familial adenomatous polyposis or a hereditary nonpolyposis colorectal cancer. We report a case of a 45-year-old woman who underwent in 1995 neuro-oncological treatment for an anaplastic astrocytoma (grade III according to the World Health Organization classification). Treatment included complete surgery, radiotherapy, a first-line nitrosourea-based chemotherapy regimen and a second-line platinium salt-based regimen. It was then noted that the patient's brother had colorectal cancer. Langue : FRANCAIS |
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