Article

Dupuytren's disease is a disorder of the palmar aponeurosis responsible for
apparition of pathological collagen cords that will gradually lead to a digital
retraction. These cords cause functional disability to the hand with a real
handicap for the patient. No curative treatment exists currently in this disease.
Injections of collagenase from Clostridium histolyticum cause lysis of the
collagen present in the cords and cause an interruption of the palmar cord. It is
a new treatment in the management of Dupuytren's disease. The use of collagenase
injection in the treatment of palmar form of Dupuytren's disease gives good
results in the short and medium terms. It is a simple, minimally invasive
treatment, several studies have proven its effectiveness and it approximates
percutaneous needle fasciotomy in its easy use and its indications. Patients
should be well informed about local reactions and transient pain with the
injection of C. histolyticum collagenase. Diffusion of this technique is still
limited by: the assessment of its cost compared to that of other methods of
treatment and particularly the needle fasciotomy, and the evaluation of results
over the long-term.
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Langue : FRANCAIS