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Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis
SLUKA KA; CHRISTY MR; PETERSON WL
ARCH PHYS MED REHABIL , 1999, vol. 80, n° 3, p. 313-317 Doc n°: 89743 Localisation : Documentation IRR Descripteurs : KA91 - PHYSIOTHERAPIE, DA521 - ARTHROSE
Article consultable sur : http://www.archives-pmr.org
OBJECTIVE: To assess the effects of heat and cold on quantifiable pain behaviors in an animal model of arthritis that minimizes the motivational-affective component of pain. DESIGN: The effects of superficial heat (40 degrees C) and cold (4 degrees C) on pain behaviors in rats with knee joint inflammation were tested before and after induction of inflammation and after treatment with heat or cold. SUBJECTS: Joint inflammation was induced in male Sprague-Dawley rats by intra-articular injection of the knee joint with 3% kaolin and 3% carrageenan. MAIN OUTCOME MEASURES: Withdrawal latency to heat applied to the paw (PWL) assessed secondary hyperalgesia; spontaneous pain behaviors assessed degree of weight bearing/ guarding; and joint circumference assessed joint swelling. RESULTS: Cold treatment of the inflamed knee joint significantly reversed the PWL immediately after treatment (p = .003) without affecting spontaneous pain behaviors orjoint circumference. In contrast, heat treatment produced a small but significant decrease in spontaneous pain behaviors Langue : ANGLAIS Identifiant basis : 1999205552 |
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