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Clinical investigation of Duchenne muscular dystrophy : interesting results in a trial of Prednisone
BROOKE MH
ARCH NEUROL , 1987, vol. 44, n° 8, p. 812-817 Doc n°: 32909 Localisation : Bibliothèque Universitaire de Médecine de Nancy Descripteurs : AB311 - MYOPATHIE DE DUCHENNE DE BOULOGNE We investigated the effect of high-dose prednisone therapy in 33 boys with Duchenne muscular dystrophy. The drug was given daily in doses of 1.5 mg/kg of body weight (to a maximum of 80 mg) for six months. Muscle strength, joint contractures, timed functional tests, functional ability, and pulmonary function were measured at the beginning and end of the treatment period. The trial was designed using natural history controls, and the power of the study was 0.80 to detect a slowing of 50% in the rate of progression. During the period of the trial, muscle strength, functional grades, timed functional tests, and pulmonary function improved. Contractures followed the expected natural history of the illness. Langue : ANGLAIS Identifiant basis : 1987002272 |
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