Article

AIM: To study the prognostic value of volumetric brain magnetic resonance imaging
(MRI) at term equivalent age (TEA) and neurological examinations at TEA and at 2
years of corrected age for long-term neuromotor outcome in infants born very
preterm. METHOD: A total of 98 infants born very preterm were included.
Structural and volumetric brain MRI and the Dubowitz neurologic examination were
done at TEA. The Hammersmith Infant Neurological Examination (HINE) was performed
at 2 years of corrected age.
The Touwen examination was used for the assessment
of minor neurological dysfunction (MND) at the age of 11 years. RESULTS: Of all
children (median birthweight 1083g [quartiles 820, 1300]; gestational age 28
5/7wks [26 4/7, 30 2/7]), 41 had simple MND, 11 had complex MND (cMND), and eight
had cerebral palsy (CP). The negative and positive predictive value of structural
brain MRI for cMND or CP was 88% and 50% respectively. Reduced volumes of total
brain tissue, frontal lobes, basal ganglia and thalami, and cerebellum associated
with cMND or CP. The results of the Dubowitz neurologic examination and the HINE
correlated with the Touwen examination. INTERPRETATION: Structural and volumetric
MRI at TEA and structured neurological examinations predict long-term neuromotor
outcome in infants born preterm.
CI - (c) 2016 Mac Keith Press.

Langue : ANGLAIS