Article

The remarkable scientific and technological advances in the field of cell
research have not been translated into viable restorative therapies for brain
disorders. In this article, we examine the best available evidence for the
clinical efficacy of reconstructive intracerebral transplantation in people with
Parkinson's disease (PD), with the aim of identifying methodological obstacles to
the translation process. The major stumbling block is the fact that the potential
contributions of people with neural grafts and the effects of the physical and
social environment in which they recover have not been adequately investigated
and applied to advancing the clinical stages of the research program. We suggest
that the biopsychosocial model along with emerging evidence of targeted
rehabilitation can provide a useful framework for conducting research and
evaluation that will ensure the best possible outcomes following intracerebral
transplantation for PD.
CI - (c) The Author(s) 2016.

Langue : ANGLAIS