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One-year follow-up of mild traumatic brain injury : Post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase
STALNACKE BM; BJORNSTIG U; KARLSSON K; SOJKA P
J REHABIL MED , 2005, vol. 37, n° 5, p. 300-305 Doc n°: 122462 Localisation : Documentation IRR Descripteurs : AF3 - TRAUMATISME CRANIEN, JF - QUALITE DE VIE Objective: To investigate, in patients with mild traumatic brain injury, serum concentrations of S-100B and neurone-specific enolase in acute phase and post-concussion symptoms, disabilities and life satisfaction 1 year after the trauma. Design: Prospective study. Patients: Eighty-eight patients (age range 18-87 years). Methods : Blood samples were taken on admission and about 7 hours later. At follow-up 15 4 months later, the patients filled in questionnaires about symptoms (Rivermead Post Concussion Symptoms), disability (Rivermead Head Injury Follow-up) and life satisfaction (LiSat-11). Results: Concentrations of S-100B and neurone-specific enolase were regularly increased in the first blood sample. Of the 69 patients participating in the follow-up, 45% reported post-concussion symptom, 48% exhibited disability and 55% were satisfied with ''life as a whole''. In comparison with the ''sick-leave'' situation on admission to hospital, 3 patients were on sick-leave at the time of follow-up because of the head trauma. Stepwise forward logistic regression analysis revealed a statistically significant association (p<0.05) between disability and S-100B and dizziness. Conclusion: In spite of frequent persistent symptoms, disabilities and low levels of life satisfaction, the sick-leave frequency was low at follow-up. The association between S-100B and disability supports the notion that long-term consequences of a mild brain injury may partly be a result of brain tissue injury. Langue : ANGLAIS |
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