Article

OBJECTIVE: To further characterize the oxygen uptake efficiency slope (OUES) in
persons with multiple sclerosis through a direct comparison with matched
controls, and by examining differences across the multiple sclerosis disability
spectrum. Also, to validate the OUES as an alternative method, which can be
derived from submaximal exercise testing, for expressing cardiorespiratory
fitness in persons with mild-to-severe multiple sclerosis. PARTICIPANTS: A total of 62 participants (Expanded Disability Status Scale (EDSS) = 1.5-6.5) with MS
and 21 non-multiple sclerosis controls completed a symptom-limited
cardiopulmonary exercise test. RESULTS: The OUES was significantly lower in
persons with multiple sclerosis (mean 1,708.5 (standard deviation (SD) 503.7))
compared with non-multiple sclerosis controls (mean 2074.2 (SD 823.2)). With
regards to the multiple sclerosis sample, there was a significant difference in
the OUES (F[2,59] = 8.9, p < 0.001, etarho2 = 0.23) across the multiple sclerosis
disability spectrum.
The OUES was significantly correlated with both OUES50
(r = 0.86)
and OUES75 (r = 0.91),
and Bland-Altman plots demonstrated agreement
between OUES and submaximal OUES values.
CONCLUSION: Overall, the OUES is a viable method for expressing cardiorespiratory fitness in individuals with
multiple sclerosis, and submaximal OUES is an appropriate alternative when
maximal exercise testing is not feasible.

Langue : ANGLAIS