Article

OBJECTIVE: To investigate the effects of a supervised longer- (14wk) versus
shorter-duration (7wk) rehabilitation program after lung transplantation (LTX).
DESIGN: Randomized controlled trial. SETTING: Outpatient rehabilitation gym
setting. PARTICIPANTS: Post-LTX patients aged >/=18 years (N=66; 33 women; mean
age, 51+/-13y) who had undergone either single LTX or bilateral LTX.
INTERVENTION: Outpatient rehabilitation program consisting of thrice-weekly
sessions with cardiovascular training on bike ergometer and treadmill plus upper
and lower limb strength training. MAIN OUTCOME MEASURES: Measures were taken at
baseline, 7 weeks, 14 weeks, and 6 months by assessors who were blinded to group
allocation. Functional exercise capacity was measured by the 6-minute walk test
(6MWT). Strength of quadriceps and hamstrings was measured on an isokinetic
dynamometer and recorded as average peak torque of 6 repetitions for both
muscles. Quality of life (QOL) was assessed with the Medical Outcomes Study
36-Item Short-Form Health Survey. RESULTS: Of the participants, 86% had bilateral
LTX and 41% had primary diagnosis of chronic obstructive pulmonary disease. The
6MWT increased in both groups with no significant difference between groups at
any time point (mean 6mo 6MWD: short, 590+/-85m vs long, 568+/-127m; P=0.5).
Similarly, at 6 months, there was no difference between groups in quadriceps
average peak torque (mean, 115+/-38Nm vs 114+/-40Nm, respectively; P=.59),
hamstring average peak torque (57+/-18Nm vs 52+/-19Nm, respectively; P=.36), or
mental or physical health domains of quality of life. CONCLUSIONS: Shorter
duration (7wk) of rehabilitation achieves comparable outcomes with 14 weeks of
supervised rehabilitation for functional exercise capacity, lower limb strength,
and quality of life at 6 months after LTX.
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