Article

PURPOSE: To investigate the association between oxygen uptake (V.O2) kinetics and
demographic, behavioral, and clinical factors among patients with peripheral
artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent
claudication performed a constant load treadmill test, and breath-by-breath
(V.e.)O2 was obtained to assess V.O2 kinetics. Demographic information,
anthropometry, cardiovascular risk factors, and comorbid conditions were
recorded. RESULTS: Using univariate analyses, higher values of tau ([tau], i.e.,
slowed V.O2 kinetics) were associated with female gender, non-Caucasian race,
hypertension, dyslipidemia, and age </=66 years. Smoking, diabetes, obesity,
metabolic syndrome, height, and ankle brachial index were not significantly
related to V.O2 kinetics. Using multiple regression procedures, the identified
predictors of slowed V.O2 kinetics were female gender (4.76 [95% CI: 1.49-8.03]
seconds; P = .0049), non-Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P =
.0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age
</=66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD
patients, slowed V.O2 kinetics are associated with demographic and clinical
factors. The clinical significance is that female, non-Caucasian, and
hypertensive PAD patients present central and/or peripheral limitations that may
partially account for their walking impairment.

Langue : ANGLAIS