Article

Objective: To determine the association between the 5 subscales of the
Multidimensional Fatigue Inventory (MFI-20) and physical function in late
mid-life. Design: Cross-sectional study. Subjects: A population-based sample of
adults who participated in the Copenhagen Aging and Midlife Biobank population
cohort (n = 4,964; age 49-63 years). Methods: Self-reported fatigue was measured
using the MFI-20 comprising: general fatigue, physical fatigue, reduced activity,
reduced motivation, and mental fatigue. Handgrip strength and chair rise tests
were used as measures of physical function. Multiple logistic regression analyses
were used to determine the associations between handgrip strength and the chair
rise test with the MFI-20 subscales, adjusted for potential confounders. Results:
After adjustments for potential confounders, handgrip strength was associated
with physical fatigue (adjusted odds ratio (OR) 0.75 (95% confidence interval
(CI) 0.66-0.86); p </= 0.001) and reduced motivation (adjusted OR 0.85 (95% CI
0.75-0.96); p </= 0.05), but not with the other subscales. After these
adjustments, the chair rise test was associated with physical fatigue (adjusted
OR 0.61 (0.53-0.69); p </= 0.001), general fatigue (adjusted OR 0.72 (0.62-0.84);
p </= 0.001), reduced activity (adjusted OR 0.79 (0.70-0.90); p </= 0.001) and
reduced motivation (adjusted OR 0.84 (0.74-0.95); p </= 0.01), but not with
mental fatigue. Subgroup analyses for sex did not show statistically significant
different associations between physical function and fatigue. Conclusion: The
present study supports the physiological basis of 4 subscales of the MFI-20. The
association between fatigue and function was independent of gender.

Langue : ANGLAIS