Article

In children with neonatal hypoxic-ischemic encephalopathy (HIE), we examined
the association between 18-month functional status by parental report and
disability at 6-7 years. METHOD: Prospective observational study involving
participants in the NICHD randomized controlled trial of hypothermia for HIE.
Parent questionnaires-Functional Status-II (FS-II), Impact on Family (IOF) and
Family Resource Scale (FRS) at 18 months were correlated with 6- to 7-year
developmental assessments. Disability at 6-7 years was defined as IQ < 70, gross
motor functional classification scale level III-V, bilateral blindness, deafness,
or epilepsy. RESULTS: Rates of severe HIE (32 vs. 15%), public insurance (73% vs.
47%) and IOF scales were higher and mean (SD) FS-II independence (I) {54 (SD 35)
vs. 98 (SD 8)} and general health (GH) {87 (SD 14) vs. 98 (SD 6)} scores were
significantly lower in children with disability (n=37) at 6-7 years, compared to
those (n=74) without disability. FS-II I scores were significantly associated
with disability (OR 0.92; 95% CI 0.87-0.97; p=0.003). On path analysis, severe
HIE, greater IOF and public insurance were associated with poorer 18-month FS-II
I scores, which, in turn, were associated with disability at 6 to 7 years.
INTERPRETATION: Poor independent functioning by parental report at 18 months in
children with HIE was associated with childhood disability.
CI - (c) 2014 Mac Keith Press.

Langue : ANGLAIS