Article

OBJECTIVE: To investigate submaximal and maximal responses during maximal
cardiopulmonary exercise tests in subjects with Parkinson disease (PD).
DESIGN: Cross-sectional.
SETTING: A PD association. PARTICIPANTS:
A sample (N=68) of
subjects with PD (n=48; mean age, 66+/-8y; modified Hoehn and Yahr stage between
2 and 3; "on" state of medication) and age-matched controls without PD (n=20;
mean age, 64+/-9y). INTERVENTIONS: Maximal cardiopulmonary exercise test on a
cycle ergometer. MAIN OUTCOME MEASURES: Oxygen uptake (V o2), systolic blood
pressure (SBP), and heart rate assessed at rest, submaximal intensities (ie,
anaerobic threshold [AT] and respiratory compensation point), and maximal
intensity (peak exercise). RESULTS: Compared with control subjects, subjects with
PD had lower V o2, heart rate, and SBP at respiratory compensation point and peak
exercise (V o2: 14.6+/-3.6mLkgmin vs 17.9+/-5.5mLkgmin and 17.7+/-4.8mLkgmin vs
21.5+/-6.6mLkgmin; heart rate: 119+/-17beats/min vs 139+/-12beats/min and
132+/-20beats/min vs 158+/-13beats/min; SBP: 151+/-17mmHg vs 172+/-20mmHg and
166+/-21mmHg vs 187+/-24mmHg; P</=.05). They also had lower heart rate at AT
(102+/-14beats/min vs 110+/-13beats/min; P</=.05), whereas V o2 and SBP at this
intensity were similar to those of control subjects. CONCLUSIONS: Subjects with
PD demonstrated blunted metabolic and cardiovascular responses to submaximal and
maximal exercise tests, especially at intensities above AT, which are in line
with autonomic disturbances present in patients with PD. Future studies need to
determine how this affects performance, participation, and responses of these
patients to exercise training at different intensities.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS