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De la psychométrie au handicap neuropsychologique dans la sclérose en plaques. Proposition d'une batterie de dépistage en langue française et facteurs de risque cognitifs
SARTORI E; BELLIARD S; CHEVRIER C; TREBON P; CHAPERON J; EDAN G
REV NEUROL (Paris) , 2006, vol. 162, n° 5, p. 603-615 Doc n°: 126018 Localisation : Documentation IRR Descripteurs : AE3 - SEP, AD6 - MANIFESTATIONS NEUROCOMPORTEMENTALES - FONCTIONS COGNITIVES Cognitive deficit in multiple sclerosis (MS) is a frequent early feature in the disease course, which conditions patients' overall disability. The goals of this study were to validate a reproducible brief screening battery written in French and to examine cognitive risk profiles in patients with a mild physical disability. METHODS: Cognitive performances of 40 patients with EDSS <4.5 were compared with those of a control group. The study was completed with an analysis of socio-demographic, clinical and psychological variables (questionnaires). RESULTS: Three tests were discriminative with satisfactory predictive values (positive: 88 percent; negative: 96 percent) and a time duration <30 minutes: PASAT (hard condition), backward digit span, learning stage of California Verbal Learning Test. Four variables were associated with cognitive deficit: educational level <11 years, age >40 years, pathological laughing-crying, unemployment. CONCLUSIONS: Our brief battery is an easy and reproducible tool. Completed with warning signs indicating the need for neuropsychological screening, this tool provides the practitioner with a global means of assessing disease activity and potentially therapeutic efficacy. Langue : FRANCAIS |
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