Article

Treatment-induced CNS toxicity remains a major cause of morbidity in patients
with cancer. Real advances in the design of safer radiation procedures have been
counterbalanced by a wider use of combined radiotherapy (RT)-chemotherapy
regimens, the development of radiosurgery, and the increasing number of long-term
survivors. While classic radionecrosis or chemonecrosis have become less common,
more subtle changes such as progressive cognitive dysfunction are increasingly
reported after RT (radiation-induced leukoencephalopathy) or chemotherapy
(administered alone or in combination). The most important and controversial
complications of RT, chemotherapy and combined treatments in the CNS are reviewed
here, including new diagnostic tools, practical management and prevention that
will influence the future management of cancer patients.
CI - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
Neurotoxicité centrale des traitements

Langue : ANGLAIS