Article

OBJECTIVE: To explore the effectiveness of platelet-rich plasma (PRP) in treating
cartilage degenerative pathology in knee joints.
DATA SOURCES: Electronic
databases, including PubMed and Scopus, were searched from the earliest record to
September 2013.
STUDY SELECTION: We included single-arm prospective studies,
quasi-experimental studies, and randomized controlled trials that used PRP to
treat knee chondral degenerative lesions. Eight single-arm studies, 3
quasi-experimental studies, and 5 randomized controlled trials were identified,
comprising 1543 participants.
DATA EXTRACTION: We determined effect sizes for the
selected studies by extracting changes in functional scales after the
interventions and compared the PRP group pooled values with the pretreatment
baseline and the groups receiving placebo or hyaluronic acid (HA) injections.
DATA SYNTHESIS: PRP injections in patients with knee degenerative pathology
showed continual efficacy for 12 months compared with their pretreatment
condition. The effectiveness of PRP was likely better and more prolonged than
that of HA. Injection doses </=2, the use of a single-spinning approach, and lack
of additional activators led to an uncertainty in the treatment effects. Patients
with lower degrees of cartilage degeneration achieved superior outcomes as
opposed to those affected by advanced osteoarthritis. CONCLUSIONS: PRP
application improves function from basal evaluations in patients with knee joint
cartilage degenerative pathology and tends to be more effective than HA
administration. Discrepancy in the degenerative severity modifies the treatment
responses, leading to participants with lower degrees of degeneration benefiting
more from PRP injections.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS