Article

Objective: To investigate the efficacy of the magnetic stimulation of inspiratory muscles as an alternative to mechanical ventilation and functional electric stimulation. Design: A prospective before-after trial. Setting: Functional magnetic stimulation laboratory in a Veterans Administration health care system. Animals: Six male mongrel dogs, each weighing between 25 and 35kg. Interventions: Commercially available magnetic stimulators with a round magnetic coil were used. The center of the magnetic coil was placed posteriorly over the C5-7 vertebrae of the spinal cord transected dogs. Magnetic stimulation parameters were set at 80% intensity, 20Hz, and a 1.2-second on and 3.8-second off pulse train. Main Outcome Measures: The major outcomes were changes in tidal volume (V-T), tracheal pressure (P-lr), and arterial partial pressure of carbon dioxide (PaCO2) and oxygen sustained by magnetic stimulation over time. Results: The average V-T and P-lr produced during functional magnetic ventilation (FMV) were .47 +/- .07L and -4.7 +/- .51 cmH(2)O, respectively. Blood gas data showed that PaCO2 increased from a baseline of 33 to 75mmHg, whereas pH decreased from 7.33 to 6.99 at the end of the 1-hour FMV period. Conclusions: FMV was achieved for 2 hours in dogs with C2 spinal cord transection. Additional refinements in magnetic stimulation are needed to improve ventilation in animals.

Langue : ANGLAIS