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Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis
STEFAN K; KUNESCH E; BENECKE R
ANN NEUROL , 2001, vol. 49, n° 4, p. 536-539 Doc n°: 100391 Localisation : Bibliothèque Universitaire de Médecine de Nancy Descripteurs : AE621 - SCLEROSE LATERALE AMYOTROPHIQUE Using transcranial magnetic stimulation, the effect of riluzole (RLZ) on cortical excitability was studied in patients with amyotrophic lateral sclerosis (ALS). Paired-pulse inhibition (PPI) and paired-pulse facilitation (PPF) were reduced. RLZ partially restored deficient PPI in the first of 4 consecutive 3-month periods of testing, but left PPF unchanged. These findings substantiate the view that attenuation of glutamate-related excitotoxicity is an important factor contributing to the beneficial effect of RLZ in ALS. Langue : ANGLAIS Identifiant basis : 2001216332 |
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