Article

Hyperlipidemia, also known as high blood cholesterol, is a cardiovascular health
risk that affects more than one third of adults in the United States. Statins are
commonly prescribed and successful lipid-lowering medications that reduce the
risks associated with cardiovascular disease. The side effects most commonly
associated with statin use involve muscle cramping, soreness, fatigue, weakness,
and, in rare cases, rapid muscle breakdown that can lead to death. Often, these
side effects can become apparent during or after strenuous bouts of exercise.
Hyperlipidémie -
risques cardiovasculaires
Although the mechanisms by which statins affect muscle performance are not
entirely understood, recent research has identified some common causative
factors. As musculoskeletal and exercise specialists, physical therapists have a
unique opportunity to identify adverse effects related to statin use. The
purposes of this perspective article are: (1) to review the metabolism and
mechanisms of actions of statins, (2) to discuss the effects of statins on
skeletal muscle function, (3) to detail the clinical presentation of
statin-induced myopathies, (4) to outline the testing used to diagnose
statin-induced myopathies, and (5) to introduce a role for the physical therapist
for the screening and detection of suspected statin-induced skeletal muscle
myopathy.

Langue : ANGLAIS