Article

Purpose: To identify case reports of statin-induced rhabdomyolysis and summarize
common predisposing factors, symptoms, diagnostic findings, functional outcomes,
characteristics, treatment, and rehabilitation. Method: MEDLINE, CINAHL, SCOPUS,
and PEDro databases were searched (1990-2013) for relevant case reports using the
search terms "Statins," "Rhabdomyolysis," "Myalgia," "Muscle damage," "Muscle
injury," and "Myopathy." Relevance (based on title and abstract) was assessed by
one investigator; two investigators independently reviewed the relevant articles
to determine inclusion in the review. Results: A total of 112 cases met the
inclusion criteria. The majority were in men (70%) and people over 45 years of
age (mean 64 [SD 14] years). Simvastatin was the most commonly reported statin
(n=55); the majority of cases reported the use of concomitant medications such as
fibrates (n=25). Weakness (n=65) and muscle pain (n=64) were the most common
symptoms. In 19 cases, the patient was referred to rehabilitation, but the case
reports do not include descriptions of the treatment. Conclusion: Statin-induced
rhabdomyolysis was more commonly reported when statins were used in conjunction
with other drugs, which potentiated its effect. Research is needed to identify
the role of exercise and rehabilitation following statin-induced rhabdomyoloysis
since muscle damage may be severe and may have long-term effects on muscle
function.

Langue : ANGLAIS