Article

OBJECTIVE: To report the prevalence of cardiometabolic risk factors in a cohort
of adults with cerebral palsy (CP) and to investigate the ability of
anthropometric measures to predict these factors. DESIGN: Cross-sectional study.
SETTING: Testing took place in a laboratory setting. PARTICIPANTS: Adults with CP
(N=55; mean age, 37.5+/-13.3 y; Gross Motor Function Classification System
levels, I-V) participated in this study. INTERVENTIONS: Not applicable. MAIN
OUTCOME MEASURES: Total cholesterol, high-density lipoprotein cholesterol,
low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and
C-reactive protein levels were measured from a fasting venous blood sample.
Insulin resistance was calculated using the Homeostasis Model Assessment
(HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC),
waist-hip ratio, and waist-height ratio were also measured. The metabolic
syndrome (MetS) was defined according to the 2009 Joint Interim Statement.
RESULTS: The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in
nonambulatory adults. BMI was associated with HOMA-IR only (beta=.451; P<.01). WC
was associated with HOMA-IR (beta=.480; P<.01), triglycerides (beta=.450; P<.01),
and systolic blood pressure (beta=.352; P<.05). Receiver operating characteristic
curve analysis revealed that WC provided the best indication of hypertensive
blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors
(area under the curve, .713-.763). CONCLUSIONS: A high prevalence of the MetS was
observed in this relatively young sample of adults with CP. WC was a better
indicator of a number of risk factors than was BMI and presents as a clinically
useful method of screening for cardiometabolic risk among adults with CP.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS