Article

Electroencephalogram Neurofeedback therapy (EEG-NFT) has several
potential beneficial effects in terms of improving cognition and
electrophysiological regulation among patients with brain injury. However, in
vivo structural and functional changes remain less explored.
The aim
of the present study is to explore EEG-NFT induced in vivo changes in traumatic
brain injury (TBI) patients. METHOD: Two patients with mean age of 15 years with
moderate head injury who had more than seven post concussion symptoms and poor
cognitive performances (<5 percentile) were subjected to 20 sessions of EEG-NFT.
The neuropsychological test scores, post concussion symptoms and MRI scan of the
brain were recorded pre-post to EEG-NFT. RESULTS: During EEG-NFT the cognitive
scores and concussion symptoms improved significantly (p < 0.05). The EEG-NFT has
shown significant increase in cortical grey matter (GM) volumes (p < 0.0001) and
fractional anisotropy (FA) of cortical white matter (WM) tracts (p < 0.0001,
voxel max 60 and above). There was a significant decrease in global, local
efficiency, cost and clustering coefficient of functional connectivity (Wilcoxon
Sign Rank Test p < 0.05). Interestingly there was a significant increase in
thalamo-cortical connection (increase FA value) after EEG-NFT. CONCLUSION: The
EEG-NFT therapy has shown significant changes in structural and functional
connectivity among young moderately injured TBI patients.

Langue : ANGLAIS