Article

BACKGROUND: Growing evidence suggests that hypovitaminosis D contributes to the
pathogenesis of multiple sclerosis (MS). OBJECTIVE:
This study aimed to evaluate
whether vitamin D levels are associated with having MS and some of its
characteristics in the Moroccan population.
METHODS: Using liquid
chromatography-tandem mass spectrometry, the 25(OH)D3 metabolite was measured to
quantify vitamin D serum levels (DSLs) in 113 patients with MS and 146 healthy
controls matched for gender and age. DSLs were then compared between patients and
controls, with correlations sought between DSLs and gender, age at onset, disease
duration, MS type, degree of disability (EDSS score) and disease severity (MSSS)
in patients. RESULTS: Hypovitaminosis D (DSL<30ng/mL) was observed in 97.3% of MS
patients and in 98.6% of controls. Although the mean DSL was slightly lower in
patients (11.69+/-6.97ng/mL) than in controls (12.98+/-6.58ng/mL), there was no
significant association between DSL and MS status (P=0.131). Similarly, among
patients, no apparent association was found between DSL and MS type (P=0.214),
EDSS score (P=0.076) or MSSS (P=0.772). CONCLUSION: Our study suggests that DSL
is not associated with having MS nor with MS type, degree of disability or
disease severity in the Moroccan population. On the other hand, DSL was lower in
women and decreased with age.
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Langue : ANGLAIS