Article

The purpose of this study was to describe cardiometabolic risk factors
and risk clustering in people with spinal cord injury (SCI). METHODS: This was a
cross-sectional study of 121 subjects aged 18 to 73 years (mean, 37 +/- 12 years)
with chronic, motor complete SCI between C5 and T12. Assessments included
demographic, social, and medical history; physical, anthropometric, and blood
pressure assessments; fasting serum assays including total cholesterol (TC),
high-density lipoprotein cholesterol (HDL-C), triglycerides, and hemoglobin A1c;
calculated low-density lipoprotein cholesterol (LDL-C); and an oral glucose
tolerance test. Framingham risk scores (FRSs) for each subject were calculated on
the basis of Third National Cholesterol Education Program Adult Treatment Panel
algorithm. RESULTS: According to FRSs, 90.1%, 8.3%, and 1.7% were classified in
the low-, medium-, and high-risk groups, respectively. The most prevalent
cardiometabolic risk factors were overweight/obesity (74%), elevated LDL-C (64%),
low HDL-C (53%), elevated systolic blood pressure (SBP, 33%), and elevated TC
(30%). Stratification by level of injury demonstrated significant differences
between paraplegic and tetraplegic participants in SBP (120 vs 99 mm Hg, P =
.0001), 2-hour glucose (101.37 vs 137.93 mg/dL, P = .0001), and 2-hour insulin
(47.45 vs 94.36 muIU/mL, P = .024). In addition, triglycerides, fasting insulin,
body mass index, LDL-C, hemoglobin A1c, and insulin resistance were significantly
associated with FRS. CONCLUSIONS: Ten percent of young people with SCI are at
moderate to high risk for long-term hard cardiac events. Overweight/obesity,
LDL-C, HDL-C, SBP, and TC were the most prevalent risk factors. Carbohydrate
metabolism is preferentially affected in persons suffering from tetraplegia,
indicating a need for impairment-specific risk assessment.

Langue : ANGLAIS

Tiré à part : OUI