Article

A major challenge for neuroimaging is to contribute to the early diagnosis of
Alzheimer's disease (AD). In particular, magnetic resonance imaging (MRI) allows
detecting different types of structural and functional abnormalities at an early
stage of the disease. Anatomical MRI is the most widely used technique and
provides local and global measures of atrophy. The recent diagnostic criteria of
"mild cognitive impairment due to AD" include hippocampal atrophy, which is
considered a marker of neuronal injury. Advanced image analysis techniques
generate automatic and reproducible measures both in the hippocampus and
throughout the whole brain. Recent modalities such as diffusion-tensor imaging
and resting-state functional MRI provide additional measures that could
contribute to the early diagnosis but require further validation.
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Langue : ANGLAIS