Article

Although the knowledge described about risk factors and venous
thromboembolism (VT) in the general population, the impact of these factors in
the development of thromboembolic events in patients with spinal injury (SI)
caused by spinal cord injury (SCI) is poorly understood.
OBJECTIVE: Evaluate the
impact of risk factors in the development of thromboembolic events in patients
with SCI. SETTING: Brazil, Sao Paulo. METHODS: Observational, prospective and
cross-study. Eligible patients (n=100) had SI by SCI, >18 years. The degree of
motor and sensory lesion was evaluated based on American Spinal Injury
Association (ASIA) Impairment Scale (AIS). Blood samples were collected for
coagulation exams, hemogram, laboratory and biochemical analyses. Ultrasonography
analyzes were performed from deep and superficial venous systems of lower limbs.
Quantitative real-time PCR experiments were performed in order to investigate
mutations in the prothrombin (G20210A) and Leiden factor V (G1691A) genes.
RESULTS: The main finding of this study was the higher occurrence of deep venous
thrombosis (DVT) in patients with Leiden factor V and hyperhomocysteinemia. There
was no association between SI for DVT, VT and thrombophilia. Also, there was no
relation between lupus anticoagulant and anti-cardiolipin. CONCLUSION: There is
an important difference in the incidence of DVT in patients with SI by acute and
chronic SCI. Therefore, the conduct of the investigation for thrombophilia should
be based on clinical factors, risk factors for DVT and family history of
thrombosis.

Langue : ANGLAIS