Article

Tissue-type plasminogen activator (tPA) is a serine protease well known to
promote fibrinolysis. This is why : its recombinant form (rtPA) can be used,
either alone or combined with thrombectomy, to promote recanalization/reperfusion
following ischemic stroke. However, its overall benefits are counteracted by some
of its side-effects, including incomplete lysis of clots, an increased risk of
hemorrhagic transformation and the possibility of neurotoxicity. Nevertheless,
better understanding of the mechanisms by which tPA influences brain function and
promotes its alteration may help in the design of new strategies to improve
stroke therapy.
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Langue : ANGLAIS