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The relation of serum leptin to body mass index and to serum cortisol in men with spinal cord injury
HUANG TS; WANG YH; CHEN SY
ARCH PHYS MED REHABIL , 2000, vol. 81, n° 12, p. 1582-1586 Doc n°: 98366 Localisation : Documentation IRR Descripteurs : AE21 - ORIGINE TRAUMATIQUE
Article consultable sur : http://www.archives-pmr.org
OBJECTIVE: To investigate the relations among serum leptin, body mass index (BMI), and various hormone levels in men with spinal cord injury (SCI). DESIGN: Cross-sectional. SETTING: University hospital that is a tertiary referral center. PARTICIPANTS: Forty-seven men with traumatic neurologically complete SCI and 47 age- and BMI-matched male controls. MAIN OUTCOME MEASURES: Baseline levels of various hormones were measured in subjects with SCI. Serum leptin and cortisol levels and BMI were measured in both groups. RESULTS: Serum leptin was significantly higher in the group with SCI than in the control group. A linear relation was found between serum leptin and BMI in both groups separately. A polynomial relation was found between serum leptin level and BMI in the group with SCI. A "J" phenomenon is noted at the lowest BMI. Serum cortisol correlated significantly with serum leptin level in the group with SCI. CONCLUSION: Sympathetic denervation, peripheral nerve palsy, recurrent infections, and possible central neurotransmitter alterations after SCI may contribute to the elevation of serum leptin level in men with SCI. Langue : ANGLAIS Identifiant basis : 2001214297 |
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