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Glucocorticoid epidural for sciatica : metabolic and endocrine sequelae
WARD A; WATSON J; WOOD P
RHEUMATOLOG , 2002, vol. 41, n° 1, p. 68-71 Doc n°: 103958 Localisation : Bibliothèque Universitaire de Médecine de Nancy Descripteurs : CE6 - TRAITEMENTS - RACHIS LOMBAL ET CHARNIERE LOMBOSACREE The study was designed to investigate the effect of epidural administration of glucocorticoid on insulin sensitivity. METHODS: Ten healthy individuals with sciatica underwent a short insulin tolerance test before and twice following (at 24 h and 1 week) a caudal epidural containing 80 mg triamcinolone. Fasting glucose, insulin and cortisol concentrations were also measured. RESULTS: The rate of glucose disappearance after insulin administration (k(ITT)) fell from 3.6%/min before the epidural to 1.9%/min 24 h afterwards (P=0.001) and returned to pretreatment values by 1 week. Significantly raised fasting insulin and glucose levels also reflected impaired insulin sensitivity immediately after the epidural. Morning cortisol levels were suppressed after the epidural (49 nmol/l at 24 h and 95 nmol/l at 1 week vs 352 nmol/l at baseline; P<0.01). CONCLUSIONS: Epidural administration of glucocorticoid results in potent suppression of insulin action and this should be taken into account when patients with diabetes require treatment for sciatica. Langue : ANGLAIS Identifiant basis : 2002219933 |
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