Article

In stroke patients with severe persistent neurological deficits, alternative
therapeutic modalities are limited. Stem cell therapy might be an opportunity
when the safety profile of this approach will be achieved. This review will give
possible mechanisms of restoration of function in animals and a statement of
clinical trials in humans. The sources of neural stem cells for therapeutic use
will be detailed. Potentials mechanisms of transplanted cell-mediated recovery
are described with a particular emphasis on ipsilesional post-stroke plasticity.
The optimal conditions for cell transplant therapy after stroke are evoked but
not yet clearly defined. Finally, since multimodality imaging will be crucial in
the post-transplantation patient assessment, the final part describes recent
advances in the in vivo monitoring of repair progress.
CI - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS ; FRANCAIS