Article

OBJECTIVE: To investigate predictors of improvement in observed ability to manage
activities of daily living as an outcome of rehabilitation in fibromyalgia.
METHODS: Exploratory analyses used data from the Interdisciplinary Rehabilitation
and Evaluation Programme for Patients with Chronic Widespread Pain (the IMPROvE
study); a randomized controlled trial including 191 females with fibromyalgia
randomized (1:1) to rehabilitation or a waiting list. The primary outcome was
observed activities of daily living ability evaluated with the Assessment of
Motor and Process Skills (AMPS) 6 months post-intervention. RESULTS: Overall,
38.7% of subjects were AMPS responders, i.e. having a clinically meaningful
improvement in AMPS activities of daily living ability measures at 6 months
post-intervention. In the exploratory analysis, only 4 baseline variables out of
the 52 analysed showed a statistically significant interaction with treatment
allocation (at the 0.05 level) indicating possible predictive value. Statistical
analyses that used continuous variables dichotomized at the median suggested a
predictive value of a low intake of weak and strong analgesics, and a high score
of current pain and total score on the Pain Detect Questionnaire. CONCLUSION: The
results of this exploratory study suggest that several subgroups of patients,
specifically those with a low baseline intake of weak and strong analgesics, and
more pronounced clinical signs of central sensitization, may gain most clinical
benefit from specialized rehabilitation when the outcome of interest is
improvement in observed activity of daily living ability.

Langue : ANGLAIS